The authors investigated the effect of individual difference in consideration of future consequences (CFC) on the uptake of the HPV vaccine among a group of young adults. A cross-sectional survey of 676 college students was conducted. Findings indicated that CFC had no direct effect on HPV vaccine uptake. However, CFC had significant effects on a number of HPV-related health beliefs in that greater CFC was associated with less perceived susceptibility to HPV, greater perceived severity of HPV, less perceived logistic/financial barriers, and higher perceived vaccine efficacy. CFC exerted a significant indirect effect on vaccine uptake through perceived vaccine efficacy. Implications of the findings for health communication are discussed.