Cytotoxicity of CdSe-based quantum dots incorporated in glass nanoparticles evaluated using human keratinocyte HaCaT cells

Biosci Biotechnol Biochem. 2016;80(1):210-3. doi: 10.1080/09168451.2015.1069702. Epub 2015 Jul 27.

Abstract

CdSe quantum dots (QDs) are potential fluorescent reagents, but leakage of Cd and Se often induces cytotoxicity. Here we prepared CdSe-based QDs with glass to reduce their leakage and examined their cytotoxicity using keratinocyte cells. The cytotoxicity of the QDs with glass was obviously lower than that of the commercial QDs with polymer, suggesting their safety for biological applications.

Keywords: CdSe; cytotoxicity; glass; polymer; quantum dot.

MeSH terms

  • Cadmium Compounds / toxicity*
  • Cell Line, Transformed
  • Cell Survival / drug effects
  • Diffusion
  • Drug Compounding
  • Glass / chemistry
  • Humans
  • Keratinocytes / cytology
  • Keratinocytes / drug effects*
  • Nanoparticles / toxicity*
  • Particle Size
  • Quantum Dots / toxicity*
  • Selenium Compounds / toxicity*

Substances

  • Cadmium Compounds
  • Selenium Compounds
  • cadmium selenide