Cytotoxic diterpenoids from Jatropha curcas cv. nigroviensrugosus CY Yang Roots

JieQing Liu; YuanFeng Yang; JianJun Xia; XuYang Li; ZhongRong Li; Lin Zhou; MingHua Qiu

doi:10.1016/j.phytochem.2015.07.002

Cytotoxic diterpenoids from Jatropha curcas cv. nigroviensrugosus CY Yang Roots

Phytochemistry. 2015 Sep:117:462-468. doi: 10.1016/j.phytochem.2015.07.002. Epub 2015 Jul 23.

Authors

JieQing Liu¹, YuanFeng Yang², JianJun Xia¹, XuYang Li², ZhongRong Li¹, Lin Zhou¹, MingHua Qiu³

Affiliations

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, People's Republic of China.
² State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, People's Republic of China; Graduate University of the Chinese Academy of Science, Beijing 100049, People's Republic of China.
³ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, People's Republic of China. Electronic address: mhchiu@mail.kib.ac.cn.

PMID: 26209936
DOI: 10.1016/j.phytochem.2015.07.002

Abstract

An investigation of phytochemicals from the roots of Jatropha curcas cv. nigroviensrugosus resulted in the isolation of twenty diterpenoids, including lathyranlactone, an unusual diterpenoid lactone possessing a 5/13/3 tricyclic skeleton, jatrocurcasenones A-E and jatrophodiones B-E, as well as 10 known analogues. All isolates were evaluated for cytotoxicity against the HL-60, SMMC-772, A-549, MCF-7 and SW480 human tumor cell lines using the MTS viability assay. Four of the known analogues showed cytotoxic activity in these cell lines, with IC50 values ranging from 2.0 to 23.0 μM. Moreover, the assessment of their cytotoxic structure-activity relationships showed the epoxy ring between C-5 and C-6 and the hydroxyl group at C-2 were the key functionalities for cytotoxicity.

Keywords: Cytotoxic activity; Diterpenoids; Euphorbiaceae; Jatropha curcas.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / pharmacology*
Cell Line, Tumor
Diterpenes / chemistry*
Diterpenes / pharmacology*
Drug Screening Assays, Antitumor
HL-60 Cells
Humans
Jatropha / chemistry*
Molecular Structure
Plant Roots / chemistry*
Structure-Activity Relationship

Substances

Antineoplastic Agents, Phytogenic
Diterpenes