Antibacterial constituents of Neohyptis paniculata

Fitoterapia. 2015 Sep:105:269-72. doi: 10.1016/j.fitote.2015.07.012. Epub 2015 Jul 21.

Abstract

A new α-pyrone, 6R-[5R,6S-diacetyloxy-1Z,3E-heptadienyl]-5,6-dihydro-2H-pyran-2one (1), along with six known compounds including an α-pyrone, flavones and terpenes was isolated from the aerial parts of Neohyptis paniculata. The structure of 1 was established unambiguously by MS and a series of 1D and 2D-NMR spectroscopic analyses. The antibacterial activity of the compounds (1-7) was investigated against five strains of multi-drug resistant (MDR) and methicillin-resistant Staphylococcus aureus and minimum inhibitory concentrations (MICs) of these compounds were found to be in the range of 64-256 μg/mL.

Keywords: 6R-[5R,6S-diacetyloxy-1Z,3E-heptadienyl]-5,6-dihydro-2H-pyran-2one; Antibacterial; Lamiaceae; Neohyptis paniculata; Staphylococcus aureus; α-Pyrone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / isolation & purification
  • Lamiaceae / chemistry*
  • Methicillin-Resistant Staphylococcus aureus / drug effects*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Plant Components, Aerial / chemistry*
  • Pyrones / chemistry*
  • Pyrones / isolation & purification

Substances

  • 6-(5,6-diacetyloxy-1,3-heptadienyl)-5,6-dihydro-2H-pyran-2-one
  • Anti-Bacterial Agents
  • Pyrones