A high-performance imaging probe with NIR luminescence and synergistically enhanced T1-T2 relaxivity for in vivo hepatic tumor targeting and multimodal imaging

Jian Liu; Zhengzheng Li; Xiangliang Yang; Weisheng Liu; Baodui Wang; Yanhong Zhu; Ketao Mu; Wenzhen Zhu

doi:10.1039/c5cc04911c

A high-performance imaging probe with NIR luminescence and synergistically enhanced T1-T2 relaxivity for in vivo hepatic tumor targeting and multimodal imaging

Chem Commun (Camb). 2015 Sep 7;51(69):13369-72. doi: 10.1039/c5cc04911c. Epub 2015 Jul 24.

Authors

Jian Liu¹, Zhengzheng Li, Xiangliang Yang, Weisheng Liu, Baodui Wang, Yanhong Zhu, Ketao Mu, Wenzhen Zhu

Affiliation

¹ Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry Lanzhou University Gansu, Lanzhou University, Lanzhou, 730000, P. R. China. wangbd@lzu.edu.cn.

PMID: 26207340
DOI: 10.1039/c5cc04911c

Abstract

A high-performance imaging probe with NIR luminescence and synergistically enhanced T1-T2 relaxivity was synthesized. This nanoprobe exhibits a relatively high tumor-targeting efficacy and enables NIR optical and T1-/T2-weighted MR imaging of hepatic tumor cells in vivo.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
Contrast Media / chemistry*
Coordination Complexes / chemistry
Fluorescent Dyes / chemistry
Gadolinium / chemistry
Humans
Liver Neoplasms / diagnostic imaging*
Liver Neoplasms / pathology
Magnetic Resonance Imaging*
Mice
Mice, Nude
Multimodal Imaging
Nanostructures / chemistry
Radiography
Spectroscopy, Near-Infrared
Transplantation, Heterologous

Substances

Contrast Media
Coordination Complexes
Fluorescent Dyes
Gadolinium