Cystic fibrosis-style changes in the early phase of pancreatitis

Anita Balázs; Péter Hegyi

doi:10.1016/j.clinre.2015.05.020

Cystic fibrosis-style changes in the early phase of pancreatitis

Clin Res Hepatol Gastroenterol. 2015 Sep:39 Suppl 1:S12-7. doi: 10.1016/j.clinre.2015.05.020. Epub 2015 Jul 20.

Authors

Anita Balázs¹, Péter Hegyi²

Affiliations

¹ First Department of Medicine, University of Szeged, Szeged, Hungary.
² First Department of Medicine, University of Szeged, Szeged, Hungary; MTA-SZTE Momentum Translational Gastroenterology Research Group, Szeged, Hungary. Electronic address: hegyi.peter@med.u-szeged.hu.

PMID: 26206571
DOI: 10.1016/j.clinre.2015.05.020

Abstract

The early phase of both acute and chronic pancreatitis can be characterized by disrupt level and function of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel, decreased bicarbonate secretion, intraductal acidosis, decrease of fluid secretion and elevation of mucoprotein levels. It is almost needless to say that these intrapancreatic changes are very similar to the pathophysiological changes observed in cystic fibrosis. The aim of this mini review is to describe the development of the above mentioned pathological observations in details, moreover highlight some future therapeutic opportunities in pancreatitis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Acidosis / complications
Alcoholism / complications
Bicarbonates / metabolism
Body Water / metabolism
Cystic Fibrosis Transmembrane Conductance Regulator / antagonists & inhibitors*
Humans
Hyperplasia
Mucus / metabolism
Pancreatic Ducts / metabolism*
Pancreatic Ducts / pathology
Pancreatitis / metabolism*

Substances

Bicarbonates
Cystic Fibrosis Transmembrane Conductance Regulator