A rapid and sensitive assay for determination of doxycycline using thioglycolic acid-capped cadmium telluride quantum dots

Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 5:152:119-25. doi: 10.1016/j.saa.2015.07.063. Epub 2015 Jul 13.

Abstract

A rapid, simple and inexpensive spectrofluorimetric sensor for determination of doxycycline based on its interaction with thioglycolic acid-capped cadmium telluride quantum dots (TGA/CdTe QDs) has been developed. Under the optimum experimental conditions, the sensor exhibited a fast response time of <10s. The results revealed that doxycycline could quench the fluorescence of TGA/CdTe QDs via electron transfer from the QDs to doxycycline through a dynamic quenching mechanism. The sensor permitted determination of doxycycline in a concentration range of 1.9×10(-6)-6.1×10(-5)molL(-1) with a detection limit of 1.1×10(-7)molL(-1). The sensor was applied for determination of doxycycline in honey and human serum samples.

Keywords: Cadmium telluride quantum dots; Doxycycline; Fluorescence detection; Sonochemical synthesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / analysis*
  • Anti-Bacterial Agents / blood*
  • Cadmium Compounds / chemistry*
  • Doxycycline / analysis*
  • Doxycycline / blood*
  • Honey / analysis
  • Humans
  • Limit of Detection
  • Quantum Dots / chemistry*
  • Quantum Dots / ultrastructure
  • Spectrometry, Fluorescence / methods
  • Tellurium / chemistry*
  • Thioglycolates / chemistry*

Substances

  • Anti-Bacterial Agents
  • Cadmium Compounds
  • Thioglycolates
  • 2-mercaptoacetate
  • Doxycycline
  • Tellurium
  • cadmium telluride