Levels of thrombopoietin in aqueous humor of patients with noninfectious acute anterior uveitis

José-Juan Mondejar; David Salom; Salvador Garcia-Delpech; Manuel Diaz-Llopis

doi:10.2147/OPTH.S56350

Levels of thrombopoietin in aqueous humor of patients with noninfectious acute anterior uveitis

Clin Ophthalmol. 2015 Jul 13:9:1285-90. doi: 10.2147/OPTH.S56350. eCollection 2015.

Authors

José-Juan Mondejar¹, David Salom², Salvador Garcia-Delpech³, Manuel Diaz-Llopis⁴

Affiliations

¹ Ophthalmology Department, School of Medicine, University of Valencia, Valencia, Spain ; Ophthalmology Department, Hospital General Universitario de Alicante, Alicante, Spain.
² Ophthalmology Department, School of Medicine, University of Valencia, Valencia, Spain ; Ophthalmology Department, Hospital de Manises, Valencia, Spain.
³ Ophthalmology Department, School of Medicine, University of Valencia, Valencia, Spain ; Ophthalmology Department, Hospital Universitario La Fe, Valencia, Spain.
⁴ Ophthalmology Department, School of Medicine, University of Valencia, Valencia, Spain.

Abstract

Purpose: To measure thrombopoietin (TPO) levels in the serum and aqueous humors of patients with noninfectious acute anterior uveitis.

Methods: A prospective, comparative, controlled study. Serum and aqueous humors were obtained from the eyes of 16 patients with noninfectious acute anterior uveitis. TPO levels were measured using an enzyme-linked immunosorbent assay (ELISA). The results obtained were compared with those of a control group.

Results: Serum concentrations of TPO were not significantly different between control individuals and patients with active anterior uveitis. Aqueous humor TPO levels were 54.46±16.24 pg/mL in the eyes of patients with uveitis, and 34.32±11.63 pg/mL in the eyes of controls. The difference between the two groups was significant (Mann-Whitney U-test for independent data, P=0.0008), with uveitis patients exhibiting significantly higher levels of TPO.

Conclusion: The high levels of TPO in the aqueous humors of uveitis patients points toward a cytoprotective role of this factor in inflammatory repair processes and the recovery of tissue homeostasis.

Keywords: TPO; acute anterior uveitis; aqueous humors; cytoprotective; serum; thrombopoietin.