Abstract
Cell-penetrating peptides provide a promising strategy for delivery of drugs across the blood-brain barrier. Here, we present an overview of CPP and peptide-mediated delivery to the central nervous system as well as a Transwell in vitro model to evaluate passage across an endothelial cell layer mimic of the blood-brain barrier.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Blood-Brain Barrier / metabolism*
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Cell Culture Techniques / instrumentation
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Cell Culture Techniques / methods
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Cell-Penetrating Peptides / chemistry
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Cell-Penetrating Peptides / metabolism*
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DNA / administration & dosage*
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DNA / chemistry
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DNA / genetics
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Equipment Design
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Gene Transfer Techniques
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Glioma / metabolism
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Humans
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Luciferases / analysis
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Luciferases / genetics
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Luminescent Measurements / methods
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Plasmids / administration & dosage*
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Plasmids / chemistry
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Plasmids / genetics
Substances
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Cell-Penetrating Peptides
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DNA
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Luciferases