Application of CPPs for Brain Delivery

Methods Mol Biol. 2015:1324:349-56. doi: 10.1007/978-1-4939-2806-4_23.

Abstract

Cell-penetrating peptides provide a promising strategy for delivery of drugs across the blood-brain barrier. Here, we present an overview of CPP and peptide-mediated delivery to the central nervous system as well as a Transwell in vitro model to evaluate passage across an endothelial cell layer mimic of the blood-brain barrier.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood-Brain Barrier / metabolism*
  • Cell Culture Techniques / instrumentation
  • Cell Culture Techniques / methods
  • Cell-Penetrating Peptides / chemistry
  • Cell-Penetrating Peptides / metabolism*
  • DNA / administration & dosage*
  • DNA / chemistry
  • DNA / genetics
  • Equipment Design
  • Gene Transfer Techniques
  • Glioma / metabolism
  • Humans
  • Luciferases / analysis
  • Luciferases / genetics
  • Luminescent Measurements / methods
  • Plasmids / administration & dosage*
  • Plasmids / chemistry
  • Plasmids / genetics

Substances

  • Cell-Penetrating Peptides
  • DNA
  • Luciferases