Passenger Mutations Identified in the Blink of an Eye

Robert Nechanitzky; Tak Wah Mak

doi:10.1016/j.immuni.2015.07.004

Passenger Mutations Identified in the Blink of an Eye

Immunity. 2015 Jul 21;43(1):9-11. doi: 10.1016/j.immuni.2015.07.004.

Authors

Robert Nechanitzky¹, Tak Wah Mak²

Affiliations

¹ The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, ON M5G 2M9, Canada.
² The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, ON M5G 2M9, Canada. Electronic address: tmak@uhnresearch.ca.

PMID: 26200008
DOI: 10.1016/j.immuni.2015.07.004

Abstract

Passenger mutations specific to particular mouse strains can distort experimental outcomes. In this issue of Immunity, Vanden Berghe et al. (2015) demonstrate that passenger mutations are frequent in most genetically engineered congenic mice and persist even after extensive backcrossing.

Publication types

Comment

MeSH terms

Animals
Genetic Variation / genetics*
Genome / genetics*
Mice, Inbred C57BL / genetics*