A top-notch dilemma: The complex role of NOTCH signaling in osteoarthritis

Anusha Ratneswaran; Frank Beier

doi:10.1126/scisignal.aac7862

A top-notch dilemma: The complex role of NOTCH signaling in osteoarthritis

Sci Signal. 2015 Jul 21;8(386):fs14. doi: 10.1126/scisignal.aac7862.

Authors

Anusha Ratneswaran¹, Frank Beier²

Affiliations

¹ Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.
² Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada. fbeier@uwo.ca.

PMID: 26198356
DOI: 10.1126/scisignal.aac7862

Abstract

A study by Liu et al. in the current issue of Science Signaling explores the complex dual role of NOTCH in the etiology of osteoarthritis by comparing gain-of-function mouse models representing aberrant pathological signaling and transient physiological signaling.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Cartilage, Articular / metabolism*
Osteoarthritis / metabolism*
Receptor, Notch1 / metabolism*
Signal Transduction*

Substances

Receptor, Notch1

Grants and funding

Canadian Institutes of Health Research/Canada