Nanocarrier-Integrated Microspheres: Nanogel Tectonic Engineering for Advanced Drug-Delivery Systems

Yoshiro Tahara; Sada-Atsu Mukai; Shin-Ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi

doi:10.1002/adma.201501557

Nanocarrier-Integrated Microspheres: Nanogel Tectonic Engineering for Advanced Drug-Delivery Systems

Adv Mater. 2015 Sep 9;27(34):5080-8. doi: 10.1002/adma.201501557. Epub 2015 Jul 21.

Authors

Yoshiro Tahara^{1

2}, Sada-Atsu Mukai^{1

2}, Shin-Ichi Sawada^{1

2}, Yoshihiro Sasaki¹, Kazunari Akiyoshi^{1

2}

Affiliations

¹ Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, 615-8510, Japan.
² Japan Science and Technology Agency (JST), The Exploratory Research for Advanced Technology (ERATO), Bio-Nanotransporter Project, Katsura Int'tech Center, Katsura, Nishikyo-ku, Kyoto, 615-8530, Japan.

PMID: 26198172
DOI: 10.1002/adma.201501557

Abstract

A nanocarrier-integrated bottom-up method is a promising strategy for advanced drug-release systems. Self-assembled nanogels, which are one of the most beneficial nanocarriers for drug-delivery systems, are tectonically integrated to prepare nanogel-crosslinked (NanoClik) microspheres. NanoClik microspheres consisting of nanogel-derived structures (observed by STED microscopy) release "drug-loaded nanogels" after hydrolysis, resulting in successful sustained drug delivery in vivo.

Keywords: drug delivery; microspheres; nanogels; polysaccharides; proteins.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Drug Carriers / chemistry*
Drug Liberation
Drug Stability
Engineering*
Hydrogels / chemistry*
Injections
Mice
Microspheres*
Models, Molecular
Molecular Conformation
Nanostructures / chemistry*

Substances

Drug Carriers
Hydrogels