Hypoxanthine: A Universal Metabolic Indicator of Training Status in Competitive Sports

Exerc Sport Sci Rev. 2015 Oct;43(4):214-21. doi: 10.1249/JES.0000000000000055.

Abstract

Cardiorespiratory and biochemical indicators typically used by contemporary elite athletes seem to have limited applicability. According to some recent studies, purine metabolism better reflects exercise response and muscle adaptation in this group. We propose using purine derivatives, especially plasma hypoxanthine concentration, as indicators of training status in consecutive training phases in highly trained athletes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Physiological / physiology*
  • Adenine Nucleotides / metabolism
  • Athletic Performance / physiology*
  • Biomarkers / blood
  • Competitive Behavior / physiology
  • Erythrocytes / metabolism
  • Humans
  • Hypoxanthine / blood*
  • Hypoxanthine Phosphoribosyltransferase / blood
  • Metabolic Networks and Pathways
  • Muscle, Skeletal / physiology*
  • Physical Education and Training*
  • Physical Endurance / physiology

Substances

  • Adenine Nucleotides
  • Biomarkers
  • Hypoxanthine
  • Hypoxanthine Phosphoribosyltransferase