Emergence of Extensively Drug-Resistant Proteus mirabilis Harboring a Conjugative NDM-1 Plasmid and a Novel Salmonella Genomic Island 1 Variant, SGI1-Z

Antimicrob Agents Chemother. 2015 Oct;59(10):6601-4. doi: 10.1128/AAC.00292-15. Epub 2015 Jul 20.

Abstract

Acquisition of blaNDM-1 in bacterial species, such as Proteus mirabilis that is intrinsically resistant to tetracycline, tigecycline and colistin, will make clinical treatment extremely difficult. Here, we characterized an NDM-1-producing clinical isolate of P. mirabilis (PM58) that displayed an extensively drug-resistant (XDR) phenotype, susceptible only to aztreonam. Molecular analysis revealed that PM58 harbored both a conjugative NDM-1 plasmid and a novel Salmonella genomic island 1 variant on chromosome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Colistin / pharmacology
  • Genome, Bacterial / genetics
  • Genomic Islands / genetics*
  • Minocycline / analogs & derivatives
  • Minocycline / pharmacology
  • Molecular Sequence Data
  • Plasmids / genetics*
  • Proteus mirabilis / genetics*
  • Salmonella / genetics
  • Tetracycline / pharmacology
  • Tigecycline

Substances

  • Anti-Bacterial Agents
  • Tigecycline
  • Tetracycline
  • Minocycline
  • Colistin

Associated data

  • GENBANK/KP662515
  • GENBANK/KP662516