Relationship between Diabetic Retinopathy and Subclinical Hypothyroidism: a meta-analysis

Jingyang Wu; Song Yue; Jin Geng; Limin Liu; Weiping Teng; Lei Liu; Lei Chen

doi:10.1038/srep12212

Relationship between Diabetic Retinopathy and Subclinical Hypothyroidism: a meta-analysis

Sci Rep. 2015 Jul 20:5:12212. doi: 10.1038/srep12212.

Authors

Jingyang Wu¹, Song Yue¹, Jin Geng¹, Limin Liu¹, Weiping Teng², Lei Liu³, Lei Chen⁴

Affiliations

¹ Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
² Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.
³ 1] Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China [2] Department of Epidemiology. School of Public Health, China Medical University, Shenyang 110001, People's Republic of China.
⁴ 1] Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China [2] Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.

Abstract

Several epidemiological studies have found a positive association between diabetic retinopathy (DR) and subclinical hypothyroidism (SCH), but the findings are varied or even contradictory. In the work, we performed a meta-analysis to ascertain the relationship between DR and SCH. We searched relevant studies on the relationship between DR and SCH. All English reports were used Medline, EMbase, Web of Science, Google scholar, and all Chinese ones used CBMDisc (Chinese Biochemical Literature on Disc) and CNKI (China National Knowledge Infrastructure) database. Meta-analysis was performed using RevMan 5.1 software. We obtained eight observational studies. Random-effects meta-analysis indicated a significant association between DR and SCH (odds ratio = 2.13, 95% confidence interval = 1.41 - 3.23, p < 0.001). Based on currently evidence, SCH is probably a significant risk factor for DR.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Case-Control Studies
Diabetic Retinopathy / complications*
Humans
Hypothyroidism / complications*
Risk Factors