In this paper a new sensing scheme by simultaneously measuring optical refractive index change and sound speed change in an optofluidic thin wall micro-bubble resonator is reported. Sensitivity of sound speed is 4.2-6.8 MHz/ (km/s) for 3 types of mechanical modes. A 2-D optical/opto-mechanical sensing map is plotted by detecting both the whispering gallery mode resonance shift and the optomechanical resonance shift. This novel scheme provides a supplementary support to optical sensing when analytes do not respond to refractive index (RI) change.