Sedentary behaviour is associated with elevated C-reactive protein levels in people with psychosis

Schizophr Res. 2015 Oct;168(1-2):461-4. doi: 10.1016/j.schres.2015.07.003. Epub 2015 Jul 15.

Abstract

Psychosis is associated with elevated inflammatory markers including C-reactive protein (CRP), a marker of cardiovascular disease (CVD) risk. Using a cross sectional design, 250 participants with established psychosis (48.2years (SD 10.2), 39.2% female) were classified as having normal (<5.0mg/μl, N=159) or high CRP levels (>5.0mg/μl, N=91). Regression analysis demonstrated that higher sedentary behaviour was associated with elevated CRP levels (β=.155, p=.01) after adjustment for confounding variables. Female gender (β=.229, p=.001), waist circumference (β=.205, p=.003) and non-white ethnicity (β=.181, p=.005) were also associated with elevated CRP. Sedentary behaviour is modifiable and increasing physical activity may reduce CRP levels.

Keywords: C-reactive protein; Cardiovascular disease; Inflammation; Psychosis; Schizophrenia; Sedentary behaviour.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / blood
  • Bipolar Disorder / epidemiology
  • Bipolar Disorder / physiopathology*
  • C-Reactive Protein / metabolism*
  • Cross-Sectional Studies
  • Depressive Disorder / epidemiology
  • Depressive Disorder / physiopathology*
  • England / epidemiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Psychotic Disorders / epidemiology
  • Psychotic Disorders / physiopathology*
  • Regression Analysis
  • Schizophrenia / epidemiology
  • Schizophrenia / physiopathology*
  • Sedentary Behavior* / ethnology
  • Sex Characteristics
  • Waist Circumference

Substances

  • Biomarkers
  • C-Reactive Protein