Controlled self-assembly of small molecule probes and the related applications in bioanalysis

Yongxin Li; Huipeng Zhou; Jian Chen; Sohail Anjum Shahzad; Cong Yu

doi:10.1016/j.bios.2015.06.067

Controlled self-assembly of small molecule probes and the related applications in bioanalysis

Biosens Bioelectron. 2016 Feb 15:76:38-53. doi: 10.1016/j.bios.2015.06.067. Epub 2015 Jul 2.

Authors

Yongxin Li¹, Huipeng Zhou¹, Jian Chen¹, Sohail Anjum Shahzad², Cong Yu³

Affiliations

¹ State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
² State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
³ State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China. Electronic address: congyu@ciac.ac.cn.

PMID: 26188711
DOI: 10.1016/j.bios.2015.06.067

Abstract

Fluorescence spectroscopy is widely used in basic research, disease diagnosis, environmental monitoring, and the development of novel bioanalytical techniques. We mainly focus on the changes in fluorescence signal originated from the controlled self-assembly of small molecule probes, including aggregation caused quenching, aggregation induced emission, controlled turn-on of probe monomer emission, and the tunable monomer-excimer transition. Recent developments in the related bioanalytical techniques have been reviewed.

Keywords: Bioanalysis; Controlled self-assembly; Fluorescence; Small molecule probe.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biosensing Techniques*
Fluorescent Dyes / chemistry
Humans
Nanoparticles / chemistry*
Perylene / chemistry
Silanes / chemistry
Spectrometry, Fluorescence / methods*

Substances

Fluorescent Dyes
Silanes
silole
Perylene