Abstract
A series of pyrimidine-embedded polyheterocycles was synthesized using a pDOS strategy in a facile manner. The resulting poly-heterocyclic core skeletons containing a unique aza-tricyclic framework allowed for diverse display of non-covalent interacting elements, which probably serve as essentials for perturbing specific non-covalent interactions between various biopolymers.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Aza Compounds / chemical synthesis
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Aza Compounds / chemistry*
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Aza Compounds / pharmacology
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HeLa Cells
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Heterocyclic Compounds, 3-Ring / chemical synthesis
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Heterocyclic Compounds, 3-Ring / chemistry*
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Heterocyclic Compounds, 3-Ring / pharmacology
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Humans
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Models, Molecular
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Pyrimidines / chemical synthesis
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Pyrimidines / chemistry*
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Pyrimidines / pharmacology
Substances
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Alkaloids
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Aza Compounds
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Heterocyclic Compounds, 3-Ring
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Pyrimidines
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pyrimidine