Photodynamic antimicrobial chemotherapy activity of (5,10,15,20-tetrakis(4-(4-carboxyphenycarbonoimidoyl)phenyl)porphyrinato) chloro gallium(III)

Spectrochim Acta A Mol Biomol Spectrosc. 2015 Dec 5:151:867-74. doi: 10.1016/j.saa.2015.06.088. Epub 2015 Jul 2.

Abstract

(5,10,15,20-Tetrakis(4-(4-carboxyphenycarbonoimidoyl)phenyl)porphyrinato) chloro gallium(III) (complex 1) was conjugated to platinum nanoparticles (PtNPs) (represented as 1-PtNPs). The resulting conjugate showed 18 nm red shift in the Soret band when compared to 1 alone. Complex 1 and 1-PtNPs showed promising photodynamic antimicrobial chemotherapy (PACT) activity against Staphylococcus aureus, Escherichia coli and Candida albicans in solution where the log reductions obtained were 4.92, 3.76, and 3.95, respectively for 1-PtNPs. The singlet oxygen quantum yields obtained were higher at 0.56 for 1-PtNPs in DMF while that of 1 was 0.52 in the same solvent. This resulted in improved PACT activity for 1-PtNPs compared to 1 alone.

Keywords: Candida albicans; Electrospinning; Escherichia coli; Gallium porphyrin; Photodynamic antimicrobial chemotherapy; Singlet oxygen; Staphylococcus aureus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / chemistry*
  • Anti-Infective Agents / pharmacology*
  • Candida albicans / drug effects
  • Escherichia coli / drug effects
  • Gallium / chemistry
  • Metal Nanoparticles / chemistry
  • Metalloporphyrins / chemistry*
  • Metalloporphyrins / pharmacology
  • Microscopy, Electron, Transmission
  • Nanofibers / chemistry
  • Photochemotherapy / methods*
  • Platinum / chemistry
  • Singlet Oxygen
  • Spectrophotometry, Ultraviolet
  • Spectroscopy, Fourier Transform Infrared
  • Staphylococcus aureus / drug effects
  • X-Ray Diffraction

Substances

  • (5,10,15,20-tetrakis(4-(4-carboxyphenycarbonoimidoyl)phenyl)porphyrinato)chlorogallium(III)
  • Anti-Infective Agents
  • Metalloporphyrins
  • Singlet Oxygen
  • Platinum
  • Gallium