New Scalarane Sesterterpenoids from the Formosan Sponge Ircinia felix

Ya-Yuan Lai; Mei-Chin Lu; Li-Hsueh Wang; Jih-Jung Chen; Lee-Shing Fang; Yang-Chang Wu; Ping-Jyun Sung

doi:10.3390/md13074296

New Scalarane Sesterterpenoids from the Formosan Sponge Ircinia felix

Mar Drugs. 2015 Jul 14;13(7):4296-309. doi: 10.3390/md13074296.

Authors

Ya-Yuan Lai^{1

2}, Mei-Chin Lu^{3

4}, Li-Hsueh Wang^{5

6}, Jih-Jung Chen⁷, Lee-Shing Fang⁸, Yang-Chang Wu^{9

10

11

12}, Ping-Jyun Sung^{13

14

15

16

17}

Affiliations

¹ Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. spire0123456@yahoo.com.tw.
² National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. spire0123456@yahoo.com.tw.
³ Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. jinx6609@nmmba.gov.tw.
⁴ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. jinx6609@nmmba.gov.tw.
⁵ Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. wanglh@nmmba.gov.tw.
⁶ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. wanglh@nmmba.gov.tw.
⁷ Department of Pharmacy & Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan. jjchen@tajen.edu.tw.
⁸ Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan. lsfang@csu.edu.tw.
⁹ School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
¹⁰ Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
¹¹ Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan. yachwu@mail.cmu.edu.tw.
¹² Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. yachwu@mail.cmu.edu.tw.
¹³ Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
¹⁴ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. pjsung@nmmba.gov.tw.
¹⁵ Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. pjsung@nmmba.gov.tw.
¹⁶ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. pjsung@nmmba.gov.tw.
¹⁷ Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan. pjsung@nmmba.gov.tw.

Abstract

Five new scalarane sesterterpenoids, felixins A-E (1-5), were isolated from the Formosan sponge Ircinia felix. The structures of scalaranes 1-5 were elucidated on the basis of spectroscopic analysis. Cytotoxicity of scalaranes 1-5 against the proliferation of a limited panel of tumor cell lines was evaluated.

Keywords: Ircinia felix; cytotoxicity; scalarane; sesterterpenoid; sponge.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology
Porifera / chemistry*
Sesterterpenes / isolation & purification*
Sesterterpenes / pharmacology
Taiwan
Terpenes / isolation & purification*

Substances

Antineoplastic Agents
Sesterterpenes
Terpenes