Synthesis, Structure and Antioxidant Activity of Cyclohexene-Fused Selenuranes and Related Derivatives

Poonam Rajesh Prasad; Harkesh B Singh; Ray J Butcher

doi:10.3390/molecules200712670

Synthesis, Structure and Antioxidant Activity of Cyclohexene-Fused Selenuranes and Related Derivatives

Molecules. 2015 Jul 13;20(7):12670-85. doi: 10.3390/molecules200712670.

Authors

Poonam Rajesh Prasad¹, Harkesh B Singh², Ray J Butcher³

Affiliations

¹ Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India. poonam@chem.iitb.ac.in.
² Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India. chhbsia@chem.iitb.ac.in.
³ Department of Chemistry, Howard University, Washington, DC 20059, USA. rbutcher99@yahoo.com.

Abstract

Synthesis, structure and antioxidant activity of new cyclohexene-fused spiroselenuranes and a spirotellurane is reported. Oxidation reactions of bis(o-formylcyclohex- 1-ene)selenide/bis(2-hydroxymethylcyclohex-1-ene)selenide provide the corresponding spiroselenuranes. The glutathione peroxidase-like activity of the newly synthesized compounds has been evaluated.

Keywords: Se–O linkage; antioxidant; glutathione peroxidase (GPx); monochalcogenides; spirodioxychalcogenuranes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antioxidants / chemical synthesis*
Biomimetic Materials / chemical synthesis*
Crystallography, X-Ray
Cyclohexenes / chemistry*
Glutathione Peroxidase / chemistry
Molecular Structure
Organoselenium Compounds / chemistry*
Spiro Compounds / chemical synthesis*
Tellurium / chemistry
Thermodynamics

Substances

Antioxidants
Cyclohexenes
Organoselenium Compounds
Spiro Compounds
cyclohexene
Glutathione Peroxidase
Tellurium