The HIV/AIDS pandemic continues to plague the world. Evaluation of oral health status is important at every stage in the management of HIV disease. Oral health services and professionals can contribute effectively to the control of HIV/AIDS through health education, patient care, infection control and surveillance. Dental professionals have an important task of determining accurate diagnosis of oral manifestations and choosing proper treatment for each case. This review provides information on HIV associated orofacial lesions, their clinical presentation and up to date treatment strategies.