Altering the Course of Small Cell Lung Cancer: Targeting Cancer Stem Cells via LSD1 Inhibition

Cancer Cell. 2015 Jul 13;28(1):4-6. doi: 10.1016/j.ccell.2015.06.011.

Abstract

In this issue of Cancer Cell, Mohammad et al. describe LSD1, a histone demethylase, as a therapeutic target in SCLC with a unique epigenetic signature to predict drug sensitivity. Inhibition of LSD1 reduces cell proliferation and stem cell maintenance while promoting cell differentiation and reducing tumor growth in preclinical models.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Benzoates / administration & dosage*
  • Cyclopropanes / administration & dosage*
  • DNA Methylation / drug effects*
  • Enzyme Inhibitors / administration & dosage*
  • Histone Demethylases / antagonists & inhibitors*
  • Humans
  • Lung Neoplasms / drug therapy*
  • Small Cell Lung Carcinoma / drug therapy*

Substances

  • Antineoplastic Agents
  • Benzoates
  • Cyclopropanes
  • Enzyme Inhibitors
  • Histone Demethylases