Bismuth coordination networks containing deferiprone: synthesis, characterisation, stability and antibacterial activity

Dalton Trans. 2015 Aug 21;44(31):13814-7. doi: 10.1039/c5dt02458g.

Abstract

A series of bismuth-dicarboxylate-deferiprone coordination networks have been prepared and structurally characterised. The new compounds have been demonstrated to release the iron overload drug deferiprone on treatment with PBS and have also been shown to have antibacterial activity against H. pylori.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Bismuth / chemistry*
  • Chemistry Techniques, Synthetic
  • Coordination Complexes / chemical synthesis*
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology*
  • Deferiprone
  • Drug Stability
  • Helicobacter pylori / drug effects
  • Models, Molecular
  • Molecular Conformation
  • Pyridones / chemistry*

Substances

  • Anti-Bacterial Agents
  • Coordination Complexes
  • Pyridones
  • Deferiprone
  • Bismuth