Abstract
The first total synthesis of amphirionin-4 has been achieved using a combination of cross-coupling strategies to access the polyene side chain and a chlorohydrin-based approach to construct the tetrahydrofuranol core. The remote C9-stereocenter was introduced through a Nozaki-Hiyama-Kishi coupling that proceeded with remote stereoinduction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biological Products / chemical synthesis*
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Biological Products / chemistry
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Dinoflagellida / chemistry
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Marine Biology
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Molecular Structure
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Polyenes / chemistry*
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Polyketides / chemical synthesis*
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Polyketides / chemistry
Substances
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Biological Products
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Polyenes
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Polyketides
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amphirionin-4