Synthesis of a new series of biologically interesting 6'-chloro-1',1'-dioxospiro[4 H-benzo[ d][1,3,7]oxadiazocine-4,3'(2' H)-[1,4,2]benzodithiazine]-2,6(1 H,5 H)dione derivatives

Zdzisław Brzozowski; Beata Żołnowska; Jarosław Sławiński

doi:10.1007/s00706-013-1010-y

Synthesis of a new series of biologically interesting 6'-chloro-1',1'-dioxospiro[4 H-benzo[ d][1,3,7]oxadiazocine-4,3'(2' H)-[1,4,2]benzodithiazine]-2,6(1 H,5 H)dione derivatives

Monatsh Chem. 2013;144(9):1397-1405. doi: 10.1007/s00706-013-1010-y. Epub 2013 Jun 11.

Authors

Zdzisław Brzozowski¹, Beata Żołnowska¹, Jarosław Sławiński¹

Affiliation

¹ Department of Organic Chemistry, Medical University of Gdańsk, Gen. J. Hallera Str. 107, 80416 Gdańsk, Poland.

Abstract

Abstract: A series of 6'-chloro-1',1'-dioxospiro[4H-benzo[d][1,3,7]oxadiazocine-4,3'(2'H)-[1,4,2]benzodithiazine]-2,6(1H,5H)dione derivatives have been synthesized from isatoic anhydride and 3-(R²-amino)-1,4,2-benzodithiazine 1,1-dioxides. Some synthetic limitations are discussed on the basis of quantum chemical calculations performed by use of the Hartree-Fock method.

Keywords: Benzodithiazine; Isatoic anhydride; Quantum chemistry; RHF; Spiro compounds; Synthesis.