Detection methods for centrifugal microfluidic platforms

Robert Burger; Letizia Amato; Anja Boisen

doi:10.1016/j.bios.2015.06.075

Detection methods for centrifugal microfluidic platforms

Biosens Bioelectron. 2016 Feb 15:76:54-67. doi: 10.1016/j.bios.2015.06.075. Epub 2015 Jul 2.

Authors

Robert Burger¹, Letizia Amato¹, Anja Boisen¹

Affiliation

¹ Department of Micro- and Nanotechnology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.

PMID: 26166363
DOI: 10.1016/j.bios.2015.06.075

Abstract

Centrifugal microfluidics has attracted much interest from academia as well as industry, since it potentially offers solutions for affordable, user-friendly and portable biosensing. A wide range of so-called fluidic unit operations, e.g. mixing, metering, liquid routing, and particle separation, have been developed and allow automation and integration of complex assay protocols in lab-on-a-disc systems. Besides liquid handling, the detection strategy for reading out the assay is crucial for developing a fully integrated system. In this review, we focus on biosensors and readout methods for the centrifugal microfluidics platform and cover optical as well as mechanical and electrical detection principles.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Automation
Biosensing Techniques / methods*
Centrifugation / methods
Equipment Design
Microfluidic Analytical Techniques / methods*
Optical Devices*