Influence of chemerin rs17173608 polymorphism on polycystic ovary syndrome susceptibility

Taiwan J Obstet Gynecol. 2015 Jun;54(3):280-3. doi: 10.1016/j.tjog.2014.05.007.

Abstract

Objective: The purpose of this study was to assess the association between the rs17173608 chemerin polymorphism and polycystic ovary syndrome risk (PCOS).

Materials and methods: This case-control study was performed on 150 patients with PCOS and 150 normal women as the control group. Tetra-amplification refractory mutation system-polymerase chain reaction was used to detect the polymorphism.

Results: Our finding showed a positive association between the chemerin gene rs17173608 polymorphism and risk of PCOS. In the dominant effect of the G allele (comparison between TG+GG and TT), TG+GG genotypes were associated with the risk of PCOS (odds ratio = 2; 95% confidence interval = 1.3-3.2, p = 0.003). The G allele is thus dominant and increases the risk of PCOS as compared to the T allele (odds ratio = 1.7, 95% confidence interval = 1.1-2.5, p = 0.009). Nonetheless, there was no significant association between chemerin rs17173608 gene polymorphism and PCOS after adjusting genotypes for body mass index and age.

Conclusion: These results suggested that there was a significant association between chemerin rs17173608 polymorphism and the PCOS; but this relationship was affected by obesity status.

Keywords: chemerin; genetic obesity; polycystic ovary syndrome; polymorphism.

MeSH terms

  • Adult
  • Age Factors
  • Alleles
  • Body Mass Index
  • Case-Control Studies
  • Chemokines / genetics*
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Intercellular Signaling Peptides and Proteins / genetics*
  • Polycystic Ovary Syndrome / genetics*
  • Polymorphism, Single Nucleotide*
  • Young Adult

Substances

  • Chemokines
  • Intercellular Signaling Peptides and Proteins
  • RARRES2 protein, human