Abstract
The controlled release of an anticancer agent from drug nanoparticles could be achieved by varying the linker length of dimeric compounds as prodrug. Notably, the cytotoxicity of the cancer cells was closely related to the release rate of drug compounds. This strategy will lead to the establishment of the novel delivery system using drug nanoparticles.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Dicarboxylic Acids / chemistry
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Dimerization
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Drug Carriers / chemistry*
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Drug Liberation*
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Humans
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Nanoparticles / chemistry*
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Podophyllotoxin / chemistry
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Prodrugs / chemistry*
Substances
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Antineoplastic Agents
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Dicarboxylic Acids
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Drug Carriers
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Prodrugs
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Podophyllotoxin