Abstract
Some novel bicyclic thiazolopyrimidine derivatives bearing various substituents have been synthesized through one-pot three-component method. Structures of the target compounds were confirmed by elemental analysis and spectral data. Some selected members of the newly synthesized compounds were investigated for their analgesic and anti-inflammatory activities and revealed pronounced anti-inflammatory activity greater than that of indomethacin (reference drug).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics* / chemical synthesis
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Analgesics* / chemistry
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Analgesics* / pharmacology
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Animals
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Anti-Inflammatory Agents* / chemical synthesis
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Anti-Inflammatory Agents* / chemistry
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Anti-Inflammatory Agents* / pharmacology
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Drug Evaluation
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Female
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Male
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Pyrimidines* / chemical synthesis
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Pyrimidines* / chemistry
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Pyrimidines* / pharmacology
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Rats
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Rats, Wistar
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Thiazoles* / chemical synthesis
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Thiazoles* / chemistry
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Thiazoles* / pharmacology
Substances
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Analgesics
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Anti-Inflammatory Agents
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Pyrimidines
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Thiazoles