Murine and human mast cell progenitors

Oliver Schmetzer; Patricia Valentin; Martin K Church; Marcus Maurer; Frank Siebenhaar

doi:10.1016/j.ejphar.2015.07.016

Murine and human mast cell progenitors

Eur J Pharmacol. 2016 May 5:778:2-10. doi: 10.1016/j.ejphar.2015.07.016. Epub 2015 Jul 8.

Authors

Oliver Schmetzer¹, Patricia Valentin¹, Martin K Church¹, Marcus Maurer¹, Frank Siebenhaar²

Affiliations

¹ Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
² Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. Electronic address: frank.siebenhaar@charite.de.

PMID: 26164789
DOI: 10.1016/j.ejphar.2015.07.016

Abstract

The development of mature mast cells (MCs) from hematopoietic progenitor cells as well as the identification and characterization of committed progenitor cells are a current focus of mast cell research. Most published reports in this area are on the origin and differentiation of MCs in mice. Evidence for the human system, i.e. derived from primary human MCs, is widely lacking. Based on the published data, MCs develop either from a committed progenitor or from a common basophil/mast cell precursor. This review summarizes the current knowledge on MC development and MC differentiation.

Keywords: Development; Differentiation; HSC; Mast cell; Progenitor.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Mast Cells / cytology*
Mast Cells / metabolism
Mice
Stem Cells / cytology*