Objective: To explore the 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET-CT) manifestations and functions in patients with primary hyperparathyroidism (pHPT).
Method: The diagnosis of 1 case of double parathyroid adenomas secondary to pPTH was reported and the related literature was reviewed.
Results: PET-CT showed two nodus shadow with slightly lower density compared with muscle, clear boundary and uniform density. Simultaneously, images also showed multiple enhanced FDG uptake of bone lesions in skeletal system. The maximum standard uptake values for ¹⁸F-FDG in the destructive bone lesions were more than 10.
Conclusion: ¹⁸F-FDG PET-CT is a well-established imaging technique for the diagnosis in pHPT. It not only can clearly visualize systemic lesions and accurately assess the extent of the disease, but also can accurately localize parathyroid adenoma. After resection of parathyroid adenoma, FDG PET-CT imaging can be useful to see the response to treatment and osteoblastic changes in brown tumor.
目的：探讨原发性甲状旁腺功能亢进症(primary hyperparathyroidism，pHPT)18-氟-2-脱氧葡萄糖[2-(fluorine-18)-fluoro-2-deoxy-D-glucose，18F-FDG]正电子发射断层显像/计算机断层成像(positron emission tomography/computed tomography，PET-CT)的表现及PET-CT在pHPT中的作用。方法：回顾分析1例经病理确诊为甲状旁腺双腺瘤继发pHPT患者的PET-CT表现，并复习有关文献，对原发甲旁亢的PET-CT表现进行总结。结果：PET-CT发现甲状腺右叶下极后方两枚较肌肉密度稍低结节影，边界清楚，密度均匀，糖代谢轻度增高，全身多发骨质破坏伴糖代谢增高，骨质破坏边界清楚，18F-FDG 最大标准摄取值达10。结论：PET-CT对pHPT的诊断有重要作用，可以准确发现全身各部位的骨质破坏及其程度，同时可以在术前进行甲状旁腺病变的定位诊断，为临床治疗提供更好依据。甲状旁腺瘤切除后，也可用PET/CT扫描来观察患者治疗后棕色瘤中成骨细胞的变化。.