Abstract
Two new phenyl derivatives (1 and 3), along with two new natural products (4 and 5), and three known compounds (2, 6 and 7), were isolated from an endophytic fungus Botryosphaeria sp. SCSIO KcF6. The structures of these compounds 1-7 were elucidated by the extensive 1D and 2D-NMR and HRESIMS Data analysis, and compared with those of reported data. The absolute configuration of the compounds 1 and 3 were assigned by optical rotation and CD data. The isolated compounds were evaluated for their cytotoxic, anti-inflammatory (COX-2) and antimicrobial activities. Compound 3 exhibited a specific COX-2 inhibitory activity with the IC50 value of 1.12 μM.
Keywords:
Botryosphaeria sp. SCSIO KcF6; COX-2 inhibitory activity; endophytic fungus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / pharmacology
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Ascomycota / chemistry*
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Ascomycota / physiology
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Biological Products / chemistry*
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Biological Products / isolation & purification
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Biological Products / pharmacology*
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Cell Line, Tumor / drug effects
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Cyclooxygenase 2 Inhibitors / chemistry
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Cyclooxygenase 2 Inhibitors / pharmacology
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Drug Evaluation, Preclinical / methods*
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Endophytes / chemistry
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Fermentation
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Humans
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Rhizophoraceae / microbiology*
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Sesquiterpenes / chemistry*
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Sesquiterpenes / pharmacology
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Wetlands
Substances
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Anti-Infective Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Antineoplastic Agents
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Biological Products
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Cyclooxygenase 2 Inhibitors
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Sesquiterpenes
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botryosphaerin A
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botryosphaerin B