Fucophlorethol C, a phlorotannin as a lipoxygenase inhibitor

Hideyuki Kurihara; Remi Konno; Koretaro Takahashi

doi:10.1080/09168451.2015.1062716

Fucophlorethol C, a phlorotannin as a lipoxygenase inhibitor

Biosci Biotechnol Biochem. 2015;79(12):1954-6. doi: 10.1080/09168451.2015.1062716. Epub 2015 Jul 9.

Authors

Hideyuki Kurihara¹, Remi Konno¹, Koretaro Takahashi¹

Affiliation

¹ a Faculty and Graduate School of Fisheries Sciences , Hokkaido University , Hakodate , Hokkaido 041-8611 , Japan.

PMID: 26155826
DOI: 10.1080/09168451.2015.1062716

Abstract

Fucophlorethol C, a phlorotannin, was isolated from the brown alga Colpomenia bullosa (Scyto-siphonaceae) as a novel lipoxygenase (LOX) inhibitor. It was obtained as a free form from natural origin for the first time. The compound inhibited a soybean LOX to the same extent as the known inhibitor nordihydroguaiaretic acid.

Keywords: Colpomenia bullosa; Fucophlorethol C; Inhibitor; Lipoxygenase; Phlorotannin.

MeSH terms

Glycine max / enzymology
Lipoxygenase Inhibitors / chemistry
Lipoxygenase Inhibitors / isolation & purification
Lipoxygenase Inhibitors / pharmacology*
Phaeophyceae / chemistry
Tannins / chemistry
Tannins / isolation & purification
Tannins / pharmacology*

Substances

Lipoxygenase Inhibitors
Tannins
fucophlorethol C