Dendritic cells (DCs) are known to regulate the functions of various immune cells. Reciprocal signaling by these immune cells also "educate" the DCs and determine the quality of the ensuing immune responses. Recently, we demonstrated that human DCs undergo maturation upon interaction with activated B cells to acquire unique abilities to promote polarization of Th2 cells.
Keywords: B lymphocytes; BAFF-R, B–cell-activating factor receptor; BCR, B-cell receptor; DAMPs, damage-associated molecular patterns; DCs, dendritic cells; OX-40 ligand; OX-40L, OX-40 ligand; PAMPs, pathogen-derived molecular patterns (PAMPs); TACI, transmembrane activator and calcium-modulating cyclophilin ligand interactor; Th2; Tregs, regulatory T cells; antibody response; antitumor; dendritic cells.