Shaping the tumor microenvironment with Modified Vaccinia Virus Ankara and TLR9 ligand

Xavier Préville; Karola Rittner; Laetitia Fend

doi:10.1080/2162402X.2014.1003013

Shaping the tumor microenvironment with Modified Vaccinia Virus Ankara and TLR9 ligand

Oncoimmunology. 2015 Feb 3;4(5):e1003013. doi: 10.1080/2162402X.2014.1003013. eCollection 2015 May.

Authors

Xavier Préville¹, Karola Rittner¹, Laetitia Fend¹

Affiliation

¹ Transgene S.A.; Illkirch-Graffenstaden ; Strasbourg, France.

Abstract

Our preclinical data demonstrate that an intravenous injection of Modified Vaccinia virus Ankara induces CD8⁺ lymphocytes to infiltrate organs to control the growth of orthotopic renal carcinoma upon combination with a toll-like receptor 9 agonist. Such shaping of the tumor microenvironment could constitute the basis of more effective clinical protocols of tumor immunotherapy.

Keywords: MUC1; MVA; TLR9; immunotherapy; orthotopic; renal carcinoma.