Direct differentiation of herbal medicine for volatile components by a multicapillary column with ion mobility spectrometry method

Qinglin Li; Rongqun Li; Gang Cao; Xin Wu; Guangming Yang; Baochang Cai; Bin Cheng; Weimin Mao

doi:10.1002/jssc.201500402

Direct differentiation of herbal medicine for volatile components by a multicapillary column with ion mobility spectrometry method

J Sep Sci. 2015 Sep;38(18):3205-3208. doi: 10.1002/jssc.201500402. Epub 2015 Aug 11.

Authors

Qinglin Li¹, Rongqun Li², Gang Cao³, Xin Wu³, Guangming Yang⁴, Baochang Cai⁴, Bin Cheng¹, Weimin Mao¹

Affiliations

¹ Zhejiang Cancer hospital, Hangzhou, P.R. China.
² College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, P.R. China.
³ Research Center of TCM Processing Technology, Zhejiang Chinese Medical University, Hangzhou, P.R. China.
⁴ School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, P.R. China.

PMID: 26152210
DOI: 10.1002/jssc.201500402

Abstract

In this work, a headspace system coupled to a gas chromatographic column and ion mobility spectrometry was applied as a screening system to differentiate the crude and processed "atractylodis macrocephalae rhizoma" samples. The obtained ion mobility data were consecutively processed by principal component analysis and Radar fingerprint chart methods. From the principal component analysis for the initial solution to original variables, the two principal components accounted for 68 and 13% of the total variance, respectively. The established method was proven to be valuable for classification, discrimination between herbal medicines from different processing procedures.

Keywords: Atractylodis macrocephalae rhizoma; Ion mobility spectrometry; Multicapillary column; Quality control.