Eosinophilic pneumonia presenting as life-threatening ARDS

BMJ Case Rep. 2015 Jul 6:2015:bcr2014207379. doi: 10.1136/bcr-2014-207379.

Abstract

We present a case of a 25-year-old woman with sudden onset of shortness of breath, cough and malaise, 24 h after discharge from a psychiatric hospital. She had been there for 2 weeks after a suicide attempt with lye, and started treatment with paroxetin, alprazolam and valproic acid. She also started smoking 20 cigarettes/day during that hospital admission. Brought to the emergency department, she evolved in the first 24 h with respiratory failure and shock needing intensive care unit (ICU) admission, with mechanical ventilation and vasopressor support. Empiric antibiotic therapy was started (piperacillin-tazobactam and azithromycin) suspecting healthcare-associated pneumonia. The patient's chest radiography progressed with bilateral infiltrates. Peripheral blood eosinophilia was seen on the second day. A bronchoalveolar lavage was performed and had 50% of eosinophils. She was started on treatment with steroids and the next day no longer needed vasopressors; 4 days later she was extubated.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Alprazolam / therapeutic use
  • Antidepressive Agents, Second-Generation / therapeutic use
  • Caustics / poisoning*
  • Cough / etiology
  • Cough / immunology
  • Drug Therapy, Combination
  • Eosinophilia / chemically induced*
  • Eosinophilia / drug therapy
  • Eosinophilia / immunology
  • Eosinophilia / pathology
  • Eosinophils
  • Female
  • Glucocorticoids / therapeutic use
  • Humans
  • Lye / poisoning*
  • Paroxetine / therapeutic use
  • Prednisone / therapeutic use
  • Pulmonary Eosinophilia / complications
  • Pulmonary Eosinophilia / diagnosis*
  • Pulmonary Eosinophilia / immunology
  • Radiography, Thoracic
  • Respiratory Distress Syndrome / diagnosis
  • Respiratory Distress Syndrome / immunology
  • Suicide, Attempted
  • Treatment Outcome
  • Valproic Acid / therapeutic use

Substances

  • Antidepressive Agents, Second-Generation
  • Caustics
  • Glucocorticoids
  • Lye
  • Paroxetine
  • Valproic Acid
  • Prednisone
  • Alprazolam