Abstract
We describe a Sabicea cinerea endophytic fungus closely related to Diaporthe pseudomangiferae that produces two known metabolites, mycoepoxydiene (1) and altiloxin A (2), as well as enamidin (3) and eremofortin F (4), two compounds not previously described in the literature. The structure of these four metabolites was elucidated using spectroscopic analysis, and their cytotoxic activities were measured against the human cell lines KB, MRC-5, and MDA-MB-435.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Ascomycota / chemistry*
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Bridged-Ring Compounds / chemistry
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Bridged-Ring Compounds / isolation & purification*
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Bridged-Ring Compounds / pharmacology
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Drug Screening Assays, Antitumor
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Endophytes / chemistry*
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Humans
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KB Cells
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Molecular Structure
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Pyrones / chemistry
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Pyrones / isolation & purification*
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Pyrones / pharmacology
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
Substances
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Antineoplastic Agents
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Bridged-Ring Compounds
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Pyrones
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Sesquiterpenes
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altiloxin A
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mycoepoxydiene