Growth of lanthanide-doped LiGdF4 nanoparticles induced by LiLuF4 core as tri-modal imaging bioprobes

Xuesong Zhai; Pengpeng Lei; Peng Zhang; Zhuo Wang; Shuyan Song; Xia Xu; Xiuling Liu; Jing Feng; Hongjie Zhang

doi:10.1016/j.biomaterials.2015.06.023

Growth of lanthanide-doped LiGdF4 nanoparticles induced by LiLuF4 core as tri-modal imaging bioprobes

Biomaterials. 2015 Oct:65:115-23. doi: 10.1016/j.biomaterials.2015.06.023. Epub 2015 Jun 15.

Authors

Xuesong Zhai¹, Pengpeng Lei², Peng Zhang³, Zhuo Wang², Shuyan Song¹, Xia Xu¹, Xiuling Liu¹, Jing Feng⁴, Hongjie Zhang⁵

Affiliations

¹ State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China.
² State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China; University of Chinese Academy of Sciences, Beijing 100049, China.
³ Department of Radiology, The Second Hospital of Jilin University, Changchun 130041, China.
⁴ State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China. Electronic address: fengj@ciac.ac.cn.
⁵ State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China. Electronic address: hongjie@ciac.ac.cn.

PMID: 26148475
DOI: 10.1016/j.biomaterials.2015.06.023

Abstract

Multimodal imaging can compensate for the deficiencies and incorporate the advantages of individual imaging modalities. In this paper, we demonstrated the synthesis of core-shell nanocomposites LiLuF4@LiGdF4:Yb,Er/Tm constituted of tetragonal LiLuF4 nanoparticles as core and Yb,Er/Tm-codoped LiGdF4 as shell. LiLuF4@LiGdF4:Yb,Er/Tm nanoparticles display brighter upconversion luminescence (UCL) than NaGdF4:Yb,Er/Tm nanoparticles with the same size under continuous-wave excitation at 980 nm. The active shell layer of LiGdF4:Yb,Er/Tm not only provide the UCL center, but also serve as magnetic resonance (MR) imaging contrast agent. To further improve the UCL intensity, the inert LiGdF4 shell was coated on the LiLuF4@LiGdF4:Yb,Er/Tm nanoparticles. Furthermore, LiLuF4@LiGdF4:Yb,Tm@LiGdF4 nanoparticles have been successfully applied to UCL/X-ray computed tomography (CT)/MR tri-modal imaging on the modal of tumor-bearing mice.

Keywords: Core–shell-shell; Lanthanide; LiGdF(4); Tri-modal imaging; Upconversion luminescence.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Contrast Media / chemistry*
Fluorides / chemistry*
Gadolinium / chemistry*
HeLa Cells
Humans
Lanthanoid Series Elements / chemistry
Lithium Compounds / chemistry*
Luminescence
Luminescent Agents / chemistry*
Lutetium / chemistry*
Magnetic Resonance Imaging / methods
Mice
Mice, Inbred BALB C
Multimodal Imaging / methods
Nanoparticles / chemistry*
Optical Imaging / methods
Tomography, X-Ray Computed / methods

Substances

Contrast Media
Lanthanoid Series Elements
Lithium Compounds
Luminescent Agents
lithium fluoride
Lutetium
Gadolinium
Fluorides