Hydrogen Peroxide Scavenging Activity of Novel Coumarins Synthesized Using Different Approaches

Ahmed A Al-Amiery; Yasameen K Al-Majedy; Abdul Amir H Kadhum; Abu Bakar Mohamad

doi:10.1371/journal.pone.0132175

Hydrogen Peroxide Scavenging Activity of Novel Coumarins Synthesized Using Different Approaches

PLoS One. 2015 Jul 6;10(7):e0132175. doi: 10.1371/journal.pone.0132175. eCollection 2015.

Authors

Ahmed A Al-Amiery¹, Yasameen K Al-Majedy², Abdul Amir H Kadhum², Abu Bakar Mohamad³

Affiliations

¹ Department of Chemical and Process Engineering, University Kebangsaan Malaysia (UKM), Bangi, Selangor, 43000, Malaysia; Environmental Research Center, University of Technology (UOT), Baghdad, 10001, Iraq.
² Environmental Research Center, University of Technology (UOT), Baghdad, 10001, Iraq.
³ Environmental Research Center, University of Technology (UOT), Baghdad, 10001, Iraq; Fuel Cell Institute, University Kebangsaan Malaysia (UKM), Bangi, Selangor, 43000, Malaysia.

Abstract

New derivatives of 7-hydroxy-4-methylcoumarin were synthesized using a chemical method and a microwave-assisted method to compare the feasibility, reaction times, and yields of the product. The newly synthesized coumarins were characterized by different spectroscopic techniques (FT-IR and NMR) and micro-elemental analysis (CHNS). In vitro antioxidant activities of these compounds were evaluated against hydrogen peroxide and were compared with standard natural antioxidant, vitamin C. Our results reveal that these compounds exhibit excellent radical scavenging activities.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Coumarins / chemical synthesis*
Coumarins / chemistry*
Free Radical Scavengers / chemical synthesis*
Free Radical Scavengers / chemistry*
Hydrogen Peroxide / chemistry*

Substances

Coumarins
Free Radical Scavengers
Hydrogen Peroxide

Grants and funding

This study was supported by the Universiti Kebangsaan Malaysia under the DIP-2012-02 grant.