The AKT1 isoform plays a dominant role in the survival and chemoresistance of chronic lymphocytic leukaemia cells

Br J Haematol. 2016 Mar;172(5):815-9. doi: 10.1111/bjh.13542. Epub 2015 Jul 6.

Sebastian W Hofbauer^{1

2}, Peter W Krenn^{1

2}, Josefina Piñόn Hofbauer^{1

2}, Susanne Pucher^{1

2}, Daniela Asslaber^{1

2}, Alexander Egle^{1

2}, Tanja N Hartmann^{3

4}, Richard Greil^{1

2}

¹ Laboratory for Immunological and Molecular Cancer Research, 3rd Medical Department with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncological Centre, Paracelsus Medical University, Salzburg, Austria.
² Salzburg Cancer Research Institute, Salzburg, Austria.
³ Laboratory for Immunological and Molecular Cancer Research, 3rd Medical Department with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncological Centre, Paracelsus Medical University, Salzburg, Austria. t.hartmann@salk.at.
⁴ Salzburg Cancer Research Institute, Salzburg, Austria. t.hartmann@salk.at.

No abstract available

Keywords: AKT; chemoresistance; chronic lymphocytic leukaemia; microenvironment; survival.

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