Plantagiolides K-N, three new withanolides and one withanolide glucoside from Tacca plantaginea

Fitoterapia. 2015 Sep:105:210-4. doi: 10.1016/j.fitote.2015.06.015. Epub 2015 Jul 2.

Abstract

Phytochemical investigation of the whole plants of Tacca plantaginea led to the isolation of 3 new withanolides and one new withanolide glucoside, named plantagiolides K-N (1-4), together with one known withanolide, 4 known withanolide glucosides, and 2 known taccalonolides. Their structures were elucidated by extensive spectroscopic analysis. Compound 4 is the first withanolide glycoside which the sugar moiety is attached at C-7. The effects of the some of isolates on TNFα-induced NF-κB transcriptional activity and cytotoxicity were evaluated.

Keywords: Cytotoxicity; Plantagiolides K–N; Tacca plantaginea; Withanolide; Withanolide glycoside.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Dioscoreaceae / chemistry*
  • Glucosides / chemistry*
  • Glucosides / isolation & purification
  • HEK293 Cells
  • Hep G2 Cells
  • Humans
  • Inhibitory Concentration 50
  • Molecular Structure
  • NF-kappa B / metabolism
  • Tumor Necrosis Factor-alpha / pharmacology
  • Withanolides / chemistry*
  • Withanolides / isolation & purification

Substances

  • Antineoplastic Agents, Phytogenic
  • Glucosides
  • NF-kappa B
  • Tumor Necrosis Factor-alpha
  • Withanolides