Pacemaker replacement in nonagenarians: Procedural safety and long-term follow-up

Arch Cardiovasc Dis. 2015 Jun-Jul;108(6-7):367-74. doi: 10.1016/j.acvd.2015.01.014. Epub 2015 Jul 2.

Abstract

Background: The rate of pacemaker implantation is rising. Given that the life expectancy of the population is projected to increase, a large number of elderly patients are likely to be implanted in the future. As pacemaker batteries can last for 8-10years, an increasing number of pacemaker recipients will require replacement of their devices when they become nonagenarians.

Aims: To analyse the short- and long-term outcomes after device replacement in nonagenarians.

Methods: Patients aged≥90years referred to a tertiary centre for pacemaker replacement from January 2004 to July 2014 were included retrospectively. Clinical follow-up data were obtained from clinical visits or telephone interviews with patients or their families. The primary clinical endpoint was total mortality. Secondary endpoints included early and delayed procedure-related complications and predictive risk factors for total mortality.

Results: Sixty-two patients were included (mean age 93.3±2.9years at time of pacemaker replacement). Mean procedure duration was 35.7±17.2minutes. Mean hospital stay was 2.2±1.1days. One patient died from a perioperative complication. Thirty-seven patients (59.7%) died during a median follow-up of 22.1months (interquartile range, 11.8-39.8months). Survival rates were 84.2% (95% confidence interval [CI] 71.8-91.5%) at 1year, 66.9% (95% CI 51.8-78.2%) at 2years and 22.7% (95% CI 10.6-37.7%) at 5years. Atrial fibrillation (hazard ratio 2.47, 95% CI 1.1-5.6) and non-physiological pacing (i.e. VVI pacing in patients in sinus rhythm) (hazard ratio 2.20, 95% CI 1.0-4.9) were predictors of mortality.

Conclusions: Pacemaker replacement in nonagenarians is a safe and straightforward procedure. These data suggest that procedures can be performed securely in this old and frail population, with patients living for a median of 30months afterwards.

Keywords: Nonagenarian; Nonagénaire; Pacemaker; Remplacement; Replacement; Stimulateur cardiaque.

MeSH terms

  • Age Factors
  • Aged, 80 and over
  • Anticoagulants / therapeutic use
  • Arrhythmias, Cardiac / therapy*
  • Atrioventricular Block / therapy
  • Cause of Death
  • Comorbidity
  • Device Removal
  • Equipment Failure
  • Female
  • Follow-Up Studies
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Mortality
  • Pacemaker, Artificial* / adverse effects
  • Platelet Aggregation Inhibitors / therapeutic use
  • Retrospective Studies
  • Risk Factors

Substances

  • Anticoagulants
  • Platelet Aggregation Inhibitors