RNA interference technology with emphasis on delivery vehicles-prospects and limitations

Shashi Prabha; Ruchi Vyas; Nidhi Gupta; Bahar Ahmed; Ramesh Chandra; Surendra Nimesh

doi:10.3109/21691401.2015.1058808

RNA interference technology with emphasis on delivery vehicles-prospects and limitations

Artif Cells Nanomed Biotechnol. 2016 Sep;44(6):1391-9. doi: 10.3109/21691401.2015.1058808. Epub 2015 Jul 3.

Authors

Shashi Prabha¹, Ruchi Vyas², Nidhi Gupta², Bahar Ahmed¹, Ramesh Chandra³, Surendra Nimesh⁴

Affiliations

¹ a Department of Pharmaceutical Chemistry , Jamia Hamdard University , New Delhi , India.
² b Department of Biotechnology , The IIS University , Jaipur , India.
³ c Department of Chemistry , University of Delhi , Delhi , India.
⁴ d Department of Biotechnology , Central University of Rajasthan, School of Life Sciences , Ajmer , India.

PMID: 26140615
DOI: 10.3109/21691401.2015.1058808

Abstract

Context: RNA interference (RNAi)-based therapeutics rely upon safe and efficient delivery of small interfering RNA (siRNA) molecules.

Objective: This review explores various dimensions of RNAi with emphasis on the development of nanoparticle-based delivery vectors for safe and efficient siRNA delivery.

Methods: An exhaustive database search has been done regarding studies done to investigate the potential of siRNA delivery employing nanoparticles has been cited in the present review.

Results and conclusion: With the current challenges, there is a need for collaborative work allowing for the successful development of nanoparticle/siRNA complexes as health-promoting biotherapeutics.

Keywords: RNA interference; gene silencing; nanoparticles; small interfering RNA; transfection.

Publication types

Review

MeSH terms

Animals
Gene Transfer Techniques*
Genetic Vectors* / chemistry
Genetic Vectors* / genetics
Humans
Nanoparticles / chemistry*
RNA Interference*
RNA, Small Interfering* / biosynthesis
RNA, Small Interfering* / genetics

Substances

RNA, Small Interfering