Aspp1: A Guardian of Hematopoietic Stem Cell Integrity

Jaroslav Zak; Xin Lu

doi:10.1016/j.stem.2015.06.012

Aspp1: A Guardian of Hematopoietic Stem Cell Integrity

Cell Stem Cell. 2015 Jul 2;17(1):3-5. doi: 10.1016/j.stem.2015.06.012.

Authors

Jaroslav Zak¹, Xin Lu²

Affiliations

¹ Ludwig Institute for Cancer Research, University of Oxford, OX3 7DQ, Oxford, UK.
² Ludwig Institute for Cancer Research, University of Oxford, OX3 7DQ, Oxford, UK. Electronic address: xin.lu@ludwig.ox.ac.uk.

PMID: 26140601
DOI: 10.1016/j.stem.2015.06.012

Abstract

Eliminating hematopoietic stem cells (HSCs) with DNA damage is necessary to maintain the homeostasis of HSCs, but the mechanisms underlying this apoptotic elimination are unclear. Now in Cell Stem Cell, Yamashita et al. (2015) show that Aspp1 coordinates with p53 to protect HSC pool integrity, guarding against hematological malignancies.

Publication types

Comment

MeSH terms

Adaptor Proteins, Signal Transducing / physiology*
Animals
Cell Transformation, Neoplastic*
Hematopoietic Stem Cells / physiology*

Substances

Adaptor Proteins, Signal Transducing