Abstract
PLA2-responsive and superparamagnetic iron oxide (SPIO) nanoparticle-loaded phospholipid micelles were developed. The release of a phospholipid-conjugated dye from these micelles was triggered due to phospholipid degradation by phospholipase A2. The high relaxivity of the encapsulated SPIO could enable non-invasive magnetic resonance imaging.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Humans
-
Magnetite Nanoparticles / chemistry*
-
Micelles*
-
Phospholipases A2 / chemistry
-
Phospholipases A2 / metabolism*
-
Phospholipids / chemistry*
-
Phospholipids / metabolism
Substances
-
Magnetite Nanoparticles
-
Micelles
-
Phospholipids
-
Phospholipases A2