Cerebral Accidents in Pediatric Diabetic Ketoacidosis: Different Complications and Different Evolutions

Horm Res Paediatr. 2015;84(2):139-44. doi: 10.1159/000382016. Epub 2015 Jun 27.

Abstract

Diabetic ketoacidosis (DKA) may be associated with neurologic complications: the most common is cerebral edema while the risk of venous and arterial stroke is rare. There is a pathogenetic link between DKA, hypercoagulability and stroke, whose risk is underestimated by clinicians. Our cases present a wide spectrum of cerebral accidents during DKA, the first one being diffuse cerebral edema, the second one venous stroke after 5 days of DKA resolution, while the third one multifocal edema suspected to be extrapontine myelinolysis although without electrolyte imbalance. Our cases suggest that DKA requires very accurate treatment, particularly at an early age, and it can be complicated by cerebral accidents even with appropriate medical care.

Publication types

  • Case Reports

MeSH terms

  • Brain Edema / etiology
  • Child
  • Diabetic Ketoacidosis / complications*
  • Diabetic Ketoacidosis / drug therapy
  • Disease Progression
  • Female
  • Fluid Therapy
  • Humans
  • Infant
  • Magnetic Resonance Imaging
  • Male
  • Stroke / etiology*
  • Treatment Outcome