Design of a hyperpolarized (15)N NMR probe that induces a large chemical-shift change upon binding of calcium ions

Chem Commun (Camb). 2015 Aug 7;51(61):12290-2. doi: 10.1039/c5cc04597e.

Abstract

Ca(2+) is a fundamental metal ion for physiological functioning. Therefore, molecular probes for Ca(2+) analysis are required. Recently, a hyperpolarized NMR probe has emerged as a promising tool. Here, we report a new design of a hyperpolarized NMR probe for Ca(2+), which showed a large chemical shift change upon binding to Ca(2+) and was applied for Ca(2+) sensing in a hyperpolarized state.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Calcium / analysis*
  • Calcium / chemistry*
  • Cations, Divalent / analysis
  • Cations, Divalent / chemistry
  • Magnetic Resonance Spectroscopy
  • Molecular Probes / analysis
  • Molecular Probes / chemistry*
  • Molecular Structure
  • Nitrogen Isotopes
  • Reference Standards

Substances

  • Cations, Divalent
  • Molecular Probes
  • Nitrogen Isotopes
  • Calcium